Scientists have discovered the mechanism through which obese individuals are
placed at a higher risk of developing complications such as type 2 diabetes.
According to a study published in Cell Metabolism, a protein known as
pigment epithelium-derived factor (PEDF) is responsible for the higher
vulnerability of obese individuals to various diseases.
High blood levels of PEDF, released into the bloodstream of overweight
individuals, desensitize the muscle and liver to insulin, resulting in insulin
resistance and the over production of insulin in the pancreas, which
subsequently leads to type 2 diabetes.
Increased blood levels of PEDF also trigger the release of fats into the
bloodstream, raising the risk of other complications such as heart disease.
"Tackling insulin resistance directly, even in the absence of weight loss,
could potentially strengthen our ability to help obese patients reduce their
risk of life-shortening disease," said Ian Campbell.
Scientists hope to lower blood fat levels, treat insulin resistance and their
subsequent complications through blocking PEDF's action.
PKH/HGH
http://www.presstv.ir/detail.aspx?id=100481