22 Apr 2008
New research suggests that not everyone who is bitten by a malaria-infected
mosquito develops life threatening health problems according to scientists
at the University of Toronto.
Malaria causes an estimated 500 million clinical cases worldwide with
symptoms ranging from headache, high fevers and nausea to more than 1
million deaths annually.
"Malaria has had a major effect on the evolution of our species. Mutations
occurring in our genome that have helped us survive malaria have been
selected for over tens of 1,000s of years of co-existing with this parasite.
Understanding how these mutations make us more resistant to malaria can help
us design innovative new strategies to prevent or treat severe malaria in
places such as sub-Saharan Africa," says researcher Kevin Kain, a Professor
out of the Department of Medicine at U of T and one of the lead researchers
on the project. "Our research shows that people who have an enzyme
deficiency or those who carry the gene trait for this deficiency may be
protected from severe and fatal malaria."
The team headed by Dr. Kain and which included researchers from McGill
University found that a deficiency in an enzyme called pyruvate kinase,
which is required for energy production in the body, provides protection
against malaria infection.
The findings could lead to the design of new novel therapies to treat and
prevent severe and fatal malaria through enhancing the body's protective
pathways instead of inundating the body with drugs. The study was funded by
the Canadian Institutes of Health Research (CIHR) Team grant in malaria.
The study findings were published in the April 24th issue of New England
Journal of Medicine.
Article adapted by Medical News Today from original press release.
Source: Christa Poole, University of Toronto
Article URL: http://www.medicalnewstoday.com/articles/104932.php