October 12, 2007
CHAPEL HILL - An intravenous "blood thinner" widely used in patients with acute
coronary syndromes and during coronary artery stent placement appears to be safe
in patients with sickle cell disease and may have beneficial anti-inflammatory
effects, a small study at the University of North Carolina at Chapel Hill School
of Medicine has found.
"We have tested a potentially promising drug in sickle cell patients, and the
drug appears to be well tolerated. This gives us the impetus to go ahead with
further studies of eptifibatide in these patients," said Dr. Leslie V. Parise,
department chair and professor of biochemistry and biophysics at the UNC-Chapel
Hill School of Medicine.
The hallmark of sickle cell disease is malformed red blood cells that can cause
sudden painful episodes when they block small blood vessels. However, sickle
cell patients are also at increased risk of developing multiple other
complications, including strokes, lung complications and pulmonary hypertension.
The most frequent manifestations of sickle cell disorders are anemia and pain
episodes. The episodic exacerbation of pain, often called "crises," is
unpredictable and may occur often in some patients.
The only drug presently approved for the treatment of sickle cell disease is
hydroxyurea, which has been shown to reduce the frequency of painful episodes.
Parise emphasized the need for further study. "We did not test this drug in
patients who are in crisis, and we cannot recommend that doctors prescribe this
drug for sickle cell patients at this time," she said.
The results of the study were published online (Oct. 6) in the British Journal
of Haematology.
The researchers gave intravenous infusions of eptifibatide (brand name
Integrilin) to four patients with sickle cell anemia who were not experiencing
pain episodes. "They did well clinically. They did not experience any
deleterious changes in their blood tests or have a pain episode," said coauthor
Dr. Kenneth I. Ataga, assistant professor of medicine at UNC-Chapel Hill.
In the current study, blood tests showed that while the patients' liver, kidney
and other functions remained at baseline, several indicators of inflammation
decreased, including levels of a protein called CD40L known to play a role in
inflammation and in blood clotting.
Previous studies conducted by Sheritha Lee a graduate student in Parise's lab
showed that patients with sickle cell disease have CD40L levels that are as much
as 30 times higher than in patients without the disease. Eptifibatide's known
ability to decrease CD40L led the researchers to study whether the drug might
help sickle cell patients.
University of North Carolina at Chapel Hill
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